Biology 1

Unit Number:

Estimated Duration:
16 days

Unit Rationale:
This unit occurs after students have gained basic knowledge of the structures and functions of the cell and its organelles in Unit 1. Through the unit, students gain an important basis in genetics that will help them understand the foundations of the many other biological concepts explored throughout the course. This unit addresses the following Indiana state standards for high school biology: B.1.7-8 (explain that complex interactions among the different kinds of molecules in the cell cause distinct cycles of activities, such as growth and division; understand and describe that all growth and development is a consequence of an increase in cell number, cell size, and/or cell products; explain that cellular differentiation results from gene expression and/or environmental influence), B.1.15 (understand and explain that, in biological systems, structure and function must be considered together), B.1.21 (understand and explain that the information passed from parents to offspring is transmitted by means of genes which are coded in DNA molecules), B.1.23-26 (Understand that and describe how inserting, deleting, or substituting DNA segments can alter a gene. Recognize that an altered gene may be passed on to every cell that develops from it, and that the resulting features may help, harm, or have little or no effect on the offspring’s success in its environment. Explain that gene mutations can be caused by such things as radiation and chemicals. Understand that when they occur in sex cells, the mutations can be passed on to offspring; if they occur in other cells, they can be passed on to descendant cells only. Explain that gene mutation in a cell can result in uncontrolled cell division, called cancer. Also know that exposure of cells to certain chemicals and radiation increases mutations and thus increases the chance of cancer. Demonstrate how the genetic information in DNA molecules provides instructions for assembling protein molecules and that this is virtually the same mechanism for all life forms.).

Unit Goal:
SWBAT analyze how changes in DNA result in gene mutations and evaluate the effects of these mutations on the cell and the organism.

Prior Knowledge:
SWBAT describe the various functions of proteins within the cell, explain the role of the nucleus in the cell, and explain the cytological basis for cancer.

Unit Assessment:
Given the function of a specific protein in the body, students will analyze a mutation in a gene partially responsible for the function of the protein and predict the mutation's potential effects on the function of the protein, the cell, and the organism. Students will be given the wild-type and mutated DNA sequences, and after transcribing and translating the sequences, students will conduct their analysis.

Lesson Plans:

Lesson Number
Number of Days
Lesson Objective
Lesson Assessment
Benchmark or Standards
LP1 2Acquring & Integrating LPs
SWBAT utilize a model of DNA to describe the process of replication.
Quiz B.1.24-25
LP2 3SWBAT explain the process of transcription and translation of a gene to create an amino acid chain.
Quiz B.1.21, B.1.26
LP3 3SWBAT apply the process of translation to analyze mutations in a gene.
Quiz B.1.23, B.1.26
LP4 2SWBAT relate the basic structure of proteins to their function.
Questioning, test
B.1.15, B.1.23
LP5 1Traditional test
LP6 2Extending & Refining LPs
SWBAT articulate how PCR mimics DNA replication to create multiple copies of a gene.
PCR Concept Check
LP7 3SWBAT analyze the effect of a DNA mutation in the MLH1 gene on the susceptibility of a patient for colon cancer
Class discussion, PA B.1.7-8, B.1.25
LP8 4Using Knowledge Meaningfully LP
SWBAT analyze the effects a mutation in a tumor suppresor gene would have on the gene itself, the cell and the organism. (Performance Assessment)
PAB.1.7-8, B.1.15, B.1.21, B.1.23-26

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