This centers-based lesson on comparing fractions with unlike denominators is designed for two-days of 45-minute lessons or one-day of a 90-minute lesson block. The lesson provides differentiated instruction using the H.O.P. Centers Framework. H.O.P. stands for Hands-On, Open-Ended, and Practice which are the themes for each of the three centers in the framework. Lesson structure is designed using brain research principles. In this lesson students will learn how to compare fractions with unlike denominators with a short engaging lesson, hands-on activity in which they explore fractions using sliced lemons, practice writing about a word problem using fractions with unlike denominators, and engage in tiered practice of the concept.